Levitra: complete medical overview, glossary and patient checklist

Disclaimer: This article is for educational purposes only and does not replace professional medical advice. Levitra (vardenafil) is a prescription medication. Always consult a qualified healthcare provider before starting, stopping, or changing any treatment.

Key terms (glossary)

Levitra

Brand name for vardenafil, a medication used to treat erectile dysfunction (ED).

Vardenafil

The active ingredient in Levitra; belongs to the class of PDE5 inhibitors.

Erectile dysfunction (ED)

Persistent difficulty achieving or maintaining an erection sufficient for sexual activity.

PDE5 inhibitor

A group of drugs that block phosphodiesterase type 5, enhancing blood flow to the penis.

Nitric oxide (NO)

A molecule released during sexual stimulation that relaxes blood vessels.

cGMP (cyclic guanosine monophosphate)

A chemical messenger that promotes smooth muscle relaxation and increased penile blood flow.

Onset of action

The time it takes for Levitra to start working (usually 25–60 minutes).

Duration of action

The period during which the medication remains effective (up to 4–5 hours).

Contraindications

Conditions or medications that make the use of Levitra unsafe.

Nitrates

Medications used for chest pain (e.g., nitroglycerin) that must not be combined with Levitra.

Alpha-blockers

Drugs used for high blood pressure or prostate enlargement that may interact with Levitra.

Priapism

A prolonged and painful erection lasting more than 4 hours; a medical emergency.

QT interval

A measurement on an ECG; Levitra may affect it in some individuals.

Cardiovascular risk

The overall risk of heart-related events, relevant when assessing ED treatment safety.

Dosage titration

Adjusting the dose based on effectiveness and tolerability.

Clear explanation

1. Causes of erectile dysfunction and why Levitra may be prescribed

Erectile dysfunction can result from vascular problems (reduced blood flow), diabetes, hypertension, hormonal imbalance, neurological conditions, psychological stress, or medication side effects. Because erections depend heavily on adequate blood flow, medications like Levitra are commonly prescribed when ED is linked to impaired vascular function.

Levitra works best in men whose ED has a physical (organic) component, although it can also help when psychological and physical causes overlap.

2. How Levitra works in the body

During sexual stimulation, nitric oxide is released in penile tissue. This increases cGMP levels, relaxing smooth muscle and allowing blood to fill the corpora cavernosa. PDE5 breaks down cGMP. Levitra (vardenafil) blocks PDE5, helping cGMP remain active longer. The result is improved blood flow and a stronger, more sustainable erection.

Important: Levitra does not cause an automatic erection. Sexual stimulation is required.

3. Manifestations and expected effects

When effective, Levitra helps:

• Improve erection firmness
• Increase ability to maintain an erection
• Enhance confidence related to sexual performance

Common side effects may include headache, facial flushing, nasal congestion, dizziness, and indigestion. These are typically mild and temporary.

4. Diagnosis before starting Levitra

Before prescribing Levitra, a clinician typically evaluates:

• Cardiovascular health
• Current medications (especially nitrates)
• History of stroke or heart attack
• Blood pressure stability
• Presence of diabetes or hormonal disorders

ED may be an early sign of cardiovascular disease. For broader health context, see our overview in 1 Win 46 and related patient education materials in 1 Win 115.

5. Treatment approaches and dosage

Levitra is typically taken 25–60 minutes before sexual activity. Standard starting doses are often 10 mg, adjusted based on response and tolerance. It should not be taken more than once per day.

Alternative PDE5 inhibitors (such as sildenafil or tadalafil) may be considered depending on patient preference, duration needs, and side-effect profile. Comparative discussions can be found in our educational section 1 Win 214.

Reader checklist

What you can do

• Consult your doctor for a full cardiovascular evaluation before starting Levitra.
• Disclose all medications and supplements you are taking.
• Take Levitra exactly as prescribed.
• Maintain a healthy lifestyle (exercise, weight control, smoking cessation).
• Monitor blood pressure if you have hypertension.

What to avoid

• Do not combine Levitra with nitrates.
• Avoid excessive alcohol consumption.
• Do not exceed the recommended dose.
• Avoid recreational drugs that affect blood pressure.
• Do not use if advised against it due to heart conditions.

When to see a doctor urgently

• Erection lasting more than 4 hours (possible priapism).
• Chest pain during sexual activity.
• Sudden vision or hearing loss.
• Severe dizziness or fainting.
• Allergic reactions (rash, swelling, difficulty breathing).

Key terms explained simply

Specialist comment (generalized)

In clinical practice, erectile dysfunction is often a marker of overall vascular health. Medications like Levitra are effective for many patients, but appropriate cardiovascular assessment and medication review are essential to ensure safe treatment.

Sources

• U.S. Food and Drug Administration (FDA). Levitra (vardenafil) prescribing information.
• European Medicines Agency (EMA). Vardenafil product information.
• American Urological Association (AUA). Erectile Dysfunction Guideline.
• Mayo Clinic. Erectile dysfunction – Diagnosis and treatment overview.

If exact dosage or safety recommendations differ, always follow official prescribing information and your physician’s advice.